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近年来认为梭形芽孢杆菌(Clostfidium difficile)是应用抗生素治疗而引起腹泻的病原。本文对53例接受1疗程抗生素治疗发生腹泻的病人的粪便进行了研究,还研究了溃疡性结肠炎26例、Crohn 病8例、非特异性腹泻49例,对照组为接受抗生素治疗而无腹泻者53例及无胃肠道症状且至少2个月未用抗生素者27例。每1例的粪便均进行了梭形芽孢杆菌培养及其毒素的检测。53例病人多数接受1种抗生素,部分为2或3种联合。结果 53例中10例粪便中含有梭形芽孢杆菌毒素,滴度10~(-2)～10~(-5),其中9例且培养出梭形芽孢杆菌。10例中1例组织学证明为伪膜性结肠炎,2例为严重的肠炎,无伪膜但有脓血便及全身症状。5例乙
In recent years, it is thought that Clostfidium difficile is a causative agent of diarrhea caused by antibiotic treatment. In this paper, 53 cases of diarrhea patients treated with a course of antibiotics were studied for stool, ulcerative colitis was also studied in 26 cases, 8 cases of Crohn disease, non-specific diarrhea in 49 cases, the control group was treated with antibiotics without diarrhea There were 27 cases with 53 cases without gastrointestinal symptoms and without antibiotics for at least 2 months. Bacillus Clostridium cultures and their toxins were tested for each of the 1 stools. Most of the 53 patients received one antibiotic, some were 2 or 3 combinations. Results Of the 53 cases, Staphylococcus aureus was present in 10 cases of stools with a titer of 10 -2 to 10 -5, of which 9 cases were Bacillus sp. One case in 10 cases was histologically proved to be pseudomembranous colitis, two cases had severe enteritis, no pseudomembranous membrane but with sepsis and systemic symptoms. 5 cases of B