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“逆流性肾病”(Reflux Nephropathy)系指膀胱输尿管返流、输尿管梗阻、慢性排斥反应等原因引起尿液在肾内逆流,从肾小管漏出,沉积在肾内静脉和间质中,可引起不同程度的血尿,并最终形成疤痕的一种病理情况。只在近年才被初步认识。“逆流性肾病”的病理特征“逆流性肾病”所表现的病理改变已发现的有: 一、静脉损害:有基底宽度不一的息肉样物质突入静脉内,息肉由含Tamm-HorsfalI蛋白(THP)的PAS阳性物质构成。大、小静脉内均可发生,周围有炎症反应存在。二、间质损害:有同样的含THP的PAS阳性物质存在,形成圆形或不规则形团块。特别在后者,常有炎性细胞,主要是嗜酸性细胞和浆细胞的浸润。有些病灶有成纤维细胞和纤维组织存在,并偶见巨细胞。
Reflux Nephropathy refers to urinary bladder reflux, ureteral obstruction, chronic rejection and other causes of urine reflux in the kidney, leakage from the renal tubules, deposition in the renal vein and interstitial can cause different The degree of hematuria, and eventually the formation of a scar pathology. Only in recent years was initially recognized. Pathological features of “reflux nephropathy” Pathological changes manifested in “refractory nephropathy” have been identified as follows: First, venous lesions: polyps of varying substrate widths protrude into the veins, and polyps are formed by the inclusion of Tamm-Horsfal I protein ) Of PAS-positive material. Large and small venous can occur, there are inflammatory reactions around. Second, interstitial damage: there is the same THP-containing PAS positive material exists, the formation of round or irregular shaped clumps. Especially in the latter, there are often infiltrating inflammatory cells, mainly eosinophils and plasma cells. Some lesions have fibroblasts and fibrous tissue, and occasionally giant cells.