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目的探讨由Ｈｐ产生的氨在Ｈｐ致病机理中的作用．方法对１６例伴有Ｈｐ感染的消化性溃疡及慢性活动性胃炎患者，应用抗菌素对症治疗４周．分别在治疗前后用尿素酶试剂药盒检查Ｈｐ感染情况，并用Ｎｅｓｌｅｒ′ｓ显色法测定治疗前后的胃液氨浓度．结果治疗后有８例患者Ｈｐ阴转，胃氨浓度由治疗前的３０５７±１９６５μｍｏｌ／Ｌ降至１７６９±９７８μｍｏｌ／Ｌ（Ｐ＜００１），同时胃粘膜病变减轻或治愈．结论氨是Ｈｐ致病的重要因素之一．动态测定胃氨浓度可以间接反映Ｈｐ的感染情况，并可以作为判定治疗效果的一项指标．
Objective To investigate the role of ammonia produced by Hp in the pathogenesis of Hp. Methods Sixteen patients with peptic ulcer associated with Hp infection and chronic active gastritis were treated with antibiotics for 4 weeks. Hp infection was examined with urease reagent kit before and after treatment, and gastric juice ammonia concentration before and after treatment was measured by Nesler’s colorimetry. Results After treatment, Hp was negative in 8 patients and the concentration of ammonia in the stomach decreased from 3057 ± 1965 μmol / L before treatment to 1769 ± 978 μmol / L (P00101), meanwhile gastric mucosal lesions Reduce or cure. Conclusion Ammonia is one of the important factors in the pathogenesis of Hp. Dynamic determination of gastric ammonia concentration can indirectly reflect the infection of Hp, and can be used as an indicator of the treatment effect.