论文部分内容阅读
To study the function of transforming growth factor β-1 (TGF-β-1) and transforming growth factor-β type II receptor (TGF-βR II) in varying stages of colorectal adenoma during neoplastic transformation, fifty-five cases of resected colorectal adenomas were examined immunohistochemically. Our results showed that the expression of TGF-β-1 ranged from high to low, with the progression of low-grade to high-grade dysplasia of adenomas to carcinoma. And there was significantly different expression of TGF-β-1 between moderate and high dysplasia adenomas (P<0.05),but no significantly different expression of TGF-β R II was found among varying stages of adenomas. Our results suggested that the quantities of TGF-β-1 secreted by adenoma cells decrease dramatically in moderate to severe dysplasia colorectal adenomas. It is the decreased secretion of TGF-β-1, rather than the mutated TGF-βR II that may play an important role in transforming colorectal adenomas to adenocarcinomas.
To study the function of transforming growth factor β-1 (TGF-β-1) and transforming growth factor-β type II receptor (TGF-βR II) in changing stages of colorectal adenoma during neoplastic transformation, fifty-five Cases of resected colorectal adenomas were examined immunohistochemically. Our results showed that the expression of TGF-β-1 ranged from high to low, with the progression of low-grade to high-grade dysplasia of adenomas to carcinoma. And there was significant Different expression of TGF-β-1 between moderate and high dysplasia adenomas (P<0.05), but no significantly different expression of TGF-β R II was found among varying stages of adenomas. Our results suggested that the quantities of TGF- β-1 secreted by adenoma cells decrease dramatically in moderate to severe dysplasia colorectal adenomas. It is the regeneration minus TGF-β-1, rather than the mutated TGF-βR II that may play an important role in transforming colorectal Adenomas to adenocarcinomas .