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配制滴眼剂,不但要考虑滴眼液的渗透压、pH值和稳定性,还应注意到无刺激性、无菌操作制备及抑菌剂的使用等问题。下面仅就这些方面谈谈个人体会。渗透压滴眼液的渗透压应尽量与泪液相等,但允许有一定范围。过去曾认为,滴眼液的渗透压必须与0.9%氯化钠溶液的渗透压相等,但根据眼睛的耐受度来观察,未损伤的眼睛可耐受较大范围的渗透压。据报道,氯化钠溶液的浓度在0.6～1.5%之间对眼睛没有什么刺激,低于或高于此浓度方能产生不适感。高渗溶液在眼内可使眼角膜组织脱水而产生不适的感
Formulated eye drops, eye drops should not only consider the osmotic pressure, pH and stability, should also be noted that non-irritating, sterile preparation and use of antibacterial agents and other issues. The following talk about personal experience in these areas. Osmotic pressure eye drops osmotic pressure should be as equal as the tear, but allows a certain range. It was previously thought that the ophthalmic solution’s osmolality must be equal to the 0.9% sodium chloride solution’s osmotic pressure, but the uninjured eye can tolerate a wide range of osmotic pressures based on the eye’s tolerance. It is reported that the concentration of sodium chloride solution between 0.6 to 1.5% of the eye no stimulation, below or above this concentration can produce discomfort. Hypertonic solution in the eye corneal tissue dehydration can produce discomfort