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复方樟脑酊为限制性药物制剂,其镇痛止咳作用主药为阿片酊。1977年版中国药典收载本品,但对其中的阿片成分未见鉴别方法。笔者曾按文献记载的Marquis法、Froehde法、重铬酸钾饱和浓硫酸显色法鉴别本品中的阿片成分,由于其它成分的干扰而影响其检出,结果不太理想,难以区别处方中是否含阿片酊成分存在。为此,我们改用氯仿提取,采用薄层层析法,同时,以原阿片碱纯品(C_(20)H_(19)O_5N)作对照,获得满意结果,现介绍如下:
Compound camphorquinone is a restrictive drug preparation and its main drug for pain relief and cough relieving is opioid spasm. The 1977 edition of the Chinese Pharmacopoeia contained this product, but there was no identification method for the opioid components. The author has identified the opioid components of this product according to the Marquis method, the Froehde method, and the colorimetric method of potassium dichromate saturated concentrated sulphuric acid in the literature. It interferes with the detection due to the interference of other components. The result is not ideal, and it is difficult to distinguish between prescriptions. Does it contain opioids? For this purpose, we used chloroform extraction and thin-layer chromatography. At the same time, the original opiate base product (C_(20)H_(19)O_5N) was used as a control to obtain satisfactory results. The following are introduced: