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目的:对3292例原发消化系统恶性肿瘤患者多重癌的发生情况进行回顾性调查。方法:对1990年1月～2001年1月11年间在我院外科住院接受手术治疗的原发消化系统恶性肿瘤患者3292例进行分析。结果:3292例原发消化系统恶性肿瘤患者中,发生多重癌73例(2.22%)。男56例,女17例(3.29:1,P<0.01)。同时癌16例(21.92%),异时癌57(78.08%)例(P<0.01)。二重癌64例(87.67%),三重癌7例(9.59%),四重癌2例(2.74%)。多重癌发生率由高到低依次为原发胰腺癌7例(10.29%)、食道癌16例(2.73%)、肠癌22(2.40%)、胃癌25(2.15%)、肝癌10(1.95%),除胃癌和肝癌外(P>0.05),差别均有统计学意义(P<0.01)。合计发生部位84处,由高到低依次为肠癌15(17.86%)、胃癌14(16.67%)、鼻咽喉癌9(10.71%)、食道癌8(9.52)、肺癌6(7.14%)、膀胱癌5(5.95%)、前列腺癌5(5.95%)、肾癌3(3.57%)、肝癌2(2.38%)、睾丸癌2(2.38%)。结论:对原发消化系统恶性肿瘤患者,提倡将整个消化道、呼吸道和泌尿道作为一个整体去对待,可以早期发现多重癌,有利于提高患者生存率。
Objective: To retrospectively investigate the occurrence of multiple cancers in 3,292 patients with primary digestive system malignancy. METHODS: A total of 3292 patients with primary digestive system malignancy who underwent surgical treatment in our hospital between January 1990 and January 2001 were analyzed. RESULTS: Of the 3292 patients with primary digestive system malignancy, 73 (2.22%) had multiple cancers. There were 56 males and 17 females (3.29:1, P<0.01). At the same time, there were 16 cases (21.92%) of cancer and 57 cases (78.08%) of different time cancer (P<0.01). There were 64 cases of double cancer (87.67%), 7 cases of triple cancer (9.59%), and 2 cases of quadruple cancer (2.74%). The incidence of multiple cancers from high to low was 7 cases of primary pancreatic cancer (10.29%), 16 cases of esophageal cancer (2.73%), 22 cases of intestinal cancer (2.40%), 25 cases of gastric cancer (2.15%), and 10 cases of liver cancer (1.95%). ), except for gastric cancer and liver cancer (P>0.05), the difference was statistically significant (P<0.01). The total occurrence of 84 sites, from high to low, followed by colorectal cancer 15 (17.86%), gastric cancer 14 (16.67%), nasopharyngeal cancer 9 (10.71%), esophageal cancer 8 (9.52), lung cancer 6 (7.14%), Bladder cancer 5 (5.95%), prostate cancer 5 (5.95%), kidney cancer 3 (3.57%), liver cancer 2 (2.38%), and testicular cancer 2 (2.38%). Conclusion: For patients with primary digestive system malignancy, it is advocated that the entire digestive tract, respiratory tract, and urinary tract should be treated as a whole. Multiple cancers can be detected early and the survival rate of patients can be improved.