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根据以往的认识,气道平滑肌完全是受胆硷能和肾上腺素能两种神经的支配.胆硷能神经兴奋时其神经末梢释放乙酰胆硷使气道平滑肌收缩,肾上腺素能神经兴奋时则释放肾上腺素类物质作用于气道平滑肌β受体使其舒张.正常生理情况下,两者处于平衡状态,以保持适度的肌张力.近年由于气道内第三神经系统(即非肾上腺素能非胆硷能神经,Non-adrenergic,non-cholinergic,简称NANC神经)的发现,对上述观点提出了新的见解.本文就气道平滑肌内NANC神经的发现、NANC神经的递质、NANC神经的生理学作用及其与临床的关系概述如下.
According to past knowledge, airway smooth muscle is completely dominated by both cholinergic and adrenergic.Cholinergic nerve is excited by the release of acetylcholine nerve endings so that airway smooth muscle contraction, adrenergic nerve excitement, then Release of adrenergic substances acting on the airway smooth muscle β receptor to make it relaxed under normal physiological conditions, the two are in balance to maintain moderate muscle tension in recent years due to the third airway nervous system (ie, non-adrenergic Found that the discovery of NANC nerve, airway smooth muscle NANC nerve transmitter, NANC nerve physiology The role and its relationship with the clinic are summarized below.