论文部分内容阅读
目的通过分析2009年山东省济宁市手足口病发病情况、住院病例、重症病例调查资料,描述手足口病流行病学特征,探索病因及其主要危险因素,为制定防控措施提供科学依据。方法从国家疾病监测信息报告管理系统中导出2009年济宁市的手足口病病例信息,进行统计分析,个案调查资料来自市疾病预防控制中心、县级疾病预防控制中心调查病例个案调查表;采集部分病例粪便标本、咽拭子、疮疹液、脑脊液、急性期血和恢复期血标本进行了实验室检测;标本检测方法参照卫生部《手足口病预防控制指南(2008年版)》规定的方法进行;以病毒分离和RT-PCR方法对2009年济宁市手足口病标本进行了病原学检测。结果共报告手足口病病例10 517例(129.21/10万),重症209例,死亡2例;采集各类标本664份,检测出103株EV71肠道病毒1,例EV71和CoxA16交叉,28株其他肠道病毒。结论手足口病发病以幼儿为主,在没有有效疫苗预防的情况下,婴幼儿和儿童普遍易感,做好儿童个人、家庭和托儿机构的防控措施的落实是预防本病的关键。
Objective To analyze the epidemiological characteristics of hand-foot-mouth disease, explore the etiology and major risk factors of hand-foot-mouth disease, hospitalization cases and serious cases in Jining City, Shandong Province in 2009 and provide scientific evidence for prevention and control measures. Methods The information of hand, foot and mouth disease cases in Jining City in 2009 was derived from the national disease surveillance information report management system, and the statistical analysis was carried out. The case investigation data were from the City Disease Prevention and Control Center and the county CDC investigation case case questionnaire. Laboratory stool specimens, throat swabs, sores, cerebrospinal fluid, acute phase blood and convalescent blood samples were tested in the laboratory. The methods for detecting specimens were performed according to the methods prescribed in the Guidelines for the Prevention and Control of Hand Foot and Mouth Disease (2008 Edition) issued by the Ministry of Public Health The pathogenicity of hand-foot-mouth disease in Jining City in 2009 was tested by virus isolation and RT-PCR. Results A total of 10517 cases of HFMD were reported (129.21 / 100 000), 209 cases of severe disease and 2 death cases. A total of 664 samples of various types were collected and 103 EV71 enterovirus strains were detected, of which EV71 and CoxA16 were cross and 28 Other enteric viruses. Conclusion The incidence of hand, foot and mouth disease is mainly young children. Infants and children are generally susceptible without effective vaccine prophylaxis. Implementing prevention and control measures for children, families and childcare institutions is the key to prevent this disease.