论文部分内容阅读
目的:观察同时应用钠通道阻滞剂和钙通道阻滞剂对鼠局灶性脑缺血的保护作用。方法:采用单尼龙线线栓法制备鼠大脑中动脉缺血3小时再灌流21小时模型,分别观察lamotrigine(20mg/kg ip),nimodipine(1μg/kg/min iv)以及两者联合应用对在鼠神经功能缺损的恢复、梗塞体积、突触体内游离钙浓度的影响。结果:联合应用lamotrigine和nimodipine缩小大鼠梗塞体积,恢复神经功能缺损较单独应用lamotrigine或nimodipine效果更明显(P<0.05)。结论:联合使用钠通道阻滞阻滞剂和钙通道阻滞剂优于单用其中一种药。
Objective: To observe the protective effect of simultaneous application of sodium channel blockers and calcium channel blockers on focal cerebral ischemia in rats. Methods: The model of middle cerebral artery occlusion (MCAO) for 3 hours and reperfusion for 21 hours was established by single nylon thread method. The effects of combination of lamotrigine (20 mg / kg ip), nimodipine (1 μg / kg / Recovery of murine neurological deficits, infarct volume, effects of synaptosomal free calcium concentration. Results: The combination of lamotrigine and nimodipine reduced infarct volume and restored neurological deficit more significantly than lamotrigine or nimodipine alone (P <0.05). Conclusion: Combination of sodium channel blockers and calcium channel blockers is superior to either alone.