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观察了离体外周血受不同剂量的紫外线照射与未受照射,以及UBI的ACVD和ACD病人的染色体(CA)和淋巴细胞胞质分裂阻断微核(CBMN)。结果表明:离体受照射的CBMN随照射剂量增加而升高,呈线性正相关(r=0.9895,P<0.01),拟合方程为Y=14.720+0.016D,而CA则无明显差异(P>0.05)。患者应用UBI的治疗前后和不同时间(1～6)年的随访观察,CA和CBMN均未发现明显差异(P>0.05)。估算每次UBI的血,受照剂量相当于受X线2cGY以下的低剂量照射,是安全的,其临床疗效可能与低剂量效应有关。
In vitro peripheral blood was observed under different doses of UV irradiation and non-irradiation, as well as UBI ACVD and ACD patient’s chromosome (CA) and lymphocyte cytokinesis block micronucleus (CBMN). The results showed that CBMN irradiated in vitro increased linearly with dose increasing (r = 0.9895, P <0.01), and the fitting equation was Y = 14.720 + 0.016D, while CA had no significant difference (P > 0.05). UBI patients before and after treatment and at different times (1 ~ 6) years of follow-up observation, CA and CBMN were found no significant difference (P> 0.05). It is safe to estimate the blood of each UBI at a dose equivalent to a low dose of 2 cGy below the X-ray, and its clinical efficacy may be related to the low-dose effect.