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盐酸胺碘酮是一种抗心律失常药 ,本文提出一种测定片剂中盐酸胺碘酮的方法。采用氧瓶燃烧及溶剂吸收将有机药物中的碘转化为碘离子 ,利用单柱阴离子交换色谱法 ,以 2 5mmol/L邻苯二甲酸、2 6mmol/L三羟甲基氨基甲烷为淋洗液 ,用直接电导法进行测定。碘离子浓度在 1 0 0～ 5 0 0mg/L范围内与峰高的响应值存在良好的线性相关关系 (相关系数为 0 9998)。经F检验 ,此法与药典所载的滴定法精密度无显著性差异 ,而且更简便 ,快速。
Amiodarone hydrochloride is an anti-arrhythmic drug, this paper presents a method for the determination of amiodarone hydrochloride tablets. The oxygen in the organic medicine was converted to iodide by the combustion of the oxygen bottle and the absorption of the solvent. Using single column anion exchange chromatography, 25 mmol / L orthophthalic acid and 26 mmol / L tris (hydroxymethyl) aminomethane as the eluent , Measured by direct conductivity method. There was a good linear correlation between the iodide ion concentration and the response of peak height in the range of 100 ~ 500 mg / L (correlation coefficient 0 9998). The F test, this method and the pharmacokinetic titration contained no significant difference in precision, but also more simple and fast.