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目的研讨阿奇霉素以序贯方式给药对小儿支原体肺炎(MPP)的治疗价值。方法选择我院2015年8月-2016年8月诊疗的48例小儿MPP病例进行试验分析,并按随机非盲法划分为两组(24例/组),Ⅰ组经静脉使用红霉素治疗,Ⅱ组以序贯方式使用阿奇霉素治疗,对两组方案的临床药效、药物副反应发生率及相关肺炎症状缓解时间等进行分析及评估。结果Ⅱ组患儿接受方案治疗后,总有效率为95.8%,药物副反应发生率为8.3%,与Ⅰ组对应数据(79.2%与29.2%)相比均显著提高或下降,有显著性差异(P<0.05)。发热、咳嗽/咳痰、肺部啰音等症状的缓解,Ⅱ组所需时间明显短于Ⅰ组,有显著性差异(P<0.05)。结论以序贯方式使用阿奇霉素对小儿MPP进行治疗,方案药效显著、安全性好,值得加强推广。
Objective To investigate the therapeutic value of azithromycin in sequential administration to children with mycoplasma pneumonia (MPP). Methods Forty-eight cases of pediatric MPP diagnosed and treated in our hospital from August 2015 to August 2016 were selected and divided into two groups (24 cases / group) randomly. The patients in group Ⅰ received intravenous erythromycin , And group Ⅱ was treated with azithromycin in a sequential manner. The clinical efficacy, the incidence of adverse drug reactions, and the time of remission related to pneumonia were analyzed and evaluated in both groups. Results After treatment, the total effective rate was 95.8% and the incidence of adverse drug reactions was 8.3% in group Ⅱ, significantly higher or lower than that in group Ⅰ (79.2% vs 29.2%), with significant difference (P <0.05). Fever, cough / expectoration, pulmonary rales and other symptoms of relief, the time required for group Ⅱ was significantly shorter than the group Ⅰ, there was a significant difference (P <0.05). Conclusion Sequential use of azithromycin in children with MPP treatment, the program efficacy is significant, good safety, it is worth to strengthen the promotion.