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目的分析ICU耐药菌肺部感染且接受机械通气治疗患者的临床资料,客观评价基于伏邪理论的清透法的临床价值。方法釆用回顾性研究方法,分析2012年1月1日—2013年12月31日中国中医科学院广安门医院ICU符合耐药菌肺部感染诊断且机械通气的患者112例,在常规治疗基础上,按是否服用清透法方药,分为治疗组58例和对照组54例。观察时间为7天和14天,比较2组患者血C-反应蛋白含量(CRP)、血小板(PLT)、耐药病原菌清除率、机械通气时间及脱机成功率等指标的变化。结果 2组治疗第7、14天后CRP、PLT比较差异有统计学意义(P<0.01);治疗组耐药病原菌清除率79.3%,对照组59.2%;2组机械通气时间及脱机成功率比较差异均有统计学意义(P<0.01)。结论基于伏邪理论的清透法可提高ICU耐药菌肺部感染且机械通气患者的耐药菌清除率,改善其机体炎症反应及凝血功能,从而降低机械通气时间,提高脱机成功率。
Objective To analyze the clinical data of ICU-resistant pulmonary infection in patients receiving mechanical ventilation and to objectively evaluate the clinical value of Qing-hua method based on the theory of voxel-evils. Methods A retrospective study was conducted to analyze 112 patients with ICU patients who were diagnosed as resistant to lung infection and resistant to antibiotic-resistant bacteria in Guang’anmen Hospital of China Academy of Traditional Chinese Medicine from January 1, 2012 to December 31, 2013. On the basis of routine treatment , According to whether to take a clear French medicine, divided into treatment group 58 cases and control group 54 cases. The observation time was 7 days and 14 days. The changes of blood levels of C-reactive protein (CRP), platelet (PLT), drug-resistant pathogen clearance, mechanical ventilation time and off-line success rate were compared between the two groups. Results The CRP and PLT in the two groups after treatment for 7 and 14 days were significantly different (P <0.01). The clearance rate of drug-resistant pathogenic bacteria in the treatment group was 79.3% and that in the control group was 59.2%. The comparison of mechanical ventilation time and success rate The differences were statistically significant (P <0.01). Conclusion Qingxue method based on voxel theory can improve the drug-resistant bacteria clearance rate, improve the inflammatory response and blood coagulation function of ICU-resistant lungs infected and mechanically ventilated patients, so as to reduce the time of mechanical ventilation and improve the success rate of off-line.