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原位癌(Bowen′s病)属于表皮内癌,其增殖的肿瘤细胞限局于表皮内,对于小的单发病灶手术切除即可,巨大或多发病例,多感处理困难,因而,希望有一种操作容易,能为患者所接受的治疗方法。常用的抗肿瘤药物有多种烷化剂、嘌呤类药物、嘧啶类药物、抗叶酸制剂和某些抗菌素等,不管那一类,由于他的细胞毒作用,都有抗肿瘤和免疫抑制作用,其毒性一般都很大,全身应用常引起肝损害和造血功能抑制等副作用。而局部应用时对于肿瘤细胞具有
Carcinoma in situ (Bowen’s disease) is an intraepidermal carcinoma whose proliferating tumor cells are localized in the epidermis. For small single lesions, surgical resection can be sufficient. For cases with large or multi-invasive cases, multi-sensory processing is difficult. Therefore, it is desirable to have a type of cancer. It is easy to operate and can be used to treat patients. Commonly used anti-cancer drugs include various alkylating agents, purine drugs, pyrimidines, anti-folic acid agents and certain antibiotics. Regardless of that type, due to his cytotoxic effects, they have anti-tumor and immunosuppressive effects. Its toxicity is generally very large, systemic applications often cause side effects such as hepatic damage and hematopoietic suppression. On the other hand, when applied topically to tumor cells