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1965年,作者为了弄清楚葡萄胎患者在吸宫时用抗肿瘤药物能否减少增生性滋养上皮病变(即局部侵犯或子宫外扩散)的发生,开始对葡萄胎患者在吸宫前后行预防性化疗。对100例葡萄胎患者在吸宫前三天开始,每天静脉滴注放线菌素D,12微克/公斤体重/日,连续5天。同期,对另100例葡萄胎患者不用化疗作为对照。5年的观察结果:在应用放线菌素D的100例中发生了2例(2%)增生性滋养上皮病变,无一例转移性滋养上皮病变,在对照
In 1965, the authors began to prevent patients with hydatidiform moles before and after uterine aspiration in order to find out whether the use of antitumor drugs during hysterectomy could reduce the occurrence of hypertrophic nourishing epithelial lesions (ie, local invasion or extrauterine spread). Chemotherapy. For 100 patients with hydatidiform mole, three days before the beginning of uterine aspiration, intravenous instillation of actinomycin D, 12 μg/kg body weight/day, was continued for 5 consecutive days. During the same period, chemotherapy was not used as a control for another 100 patients with hydatidiform mole. Five-year observation: Two cases (2%) of hypertrophic nourishing epithelial lesions occurred in 100 patients treated with actinomycin D, and none had metastatic nourishing epithelial lesions.