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以３，５双叔丁基４羟基苯基为结构单元设计合成了取代的酰芳胺、芳酯和查尔酮类化合物，模拟全反式维甲酸的分子形状、长度和功能基的空间配置，并研究对细胞诱导分化的活性。结果表明分子一端的疏水性基团，另一端羧基的存在以及分子的共轭性，是呈现诱导分化活性的必要和充分的因素，缺少其中任何一个则失去活性，而且分子的构象、形状和基团的配置也起关键作用。芳酰胺类的Ｎ甲基化产物的稳定构象是两个芳环呈顺式排布，使分子成弯曲状，而不呈反式的伸展形式，以致与全反式维甲酸分子的伸展形状不同，这是它失去活性的原因。本工作发现化合物Ｎｏ４ｆ，４ｇ，７，１３，３２，３７和３８等具有显著的细胞诱导分化作用。
Substituted 3,5-di-tert-butyl-4-hydroxyphenyl was used as the structural unit to design and synthesize the substituted aryl aromatic amides, aryl esters and chalcones to simulate the molecular shape, length and functional groups of all-trans retinoic acid The spatial configuration and study of cell-induced differentiation activity. The results show that the hydrophobic group at one end of the molecule, the presence of the carboxyl group at the other end, and the conjugation of the molecule are both necessary and sufficient contributors to the differentiation-inducing activity without the loss of any one of them, and the conformation, shape and basis of the molecule Mission configuration also plays a key role. The stable conformation of N-methylated products of aromatic amides is that the two aromatic rings are arranged in a cis-arrangement to make the molecules into a curved shape instead of a trans-extended form, so that the stretching shape of the all-trans retinoic acid molecule Different, this is the reason why it lost its activity. This work found that compounds No4f, 4g, 7,13,32,37 and 38 have significant cell-induced differentiation.