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目的:评价黄连素治疗多囊卵巢综合症(Polycystic ovary syndrome,PCOS)胰岛素抵抗(IR)有效性、安全性。方法:2014年1月~2014年12月,医院收治的74例PCOS-IR患者,据入院顺序,将患者随机分为对照组、观察组各37例,在给予基础的炔雌醇环丙孕酮片调节治疗后,分别给予二甲双弧、黄连素治疗,3个月后对比疗效与相关指标。结果:观察组与对照组临床疗效、体重下降、BBT总双相周期差异无统计学意义(P>0.05),观察组血脂紊乱率、不良反应发生率低于对照组,治疗后两组证候积分低于治疗前,差异具有统计学意义(P<0.05)。结论:黄连素治疗PCOS-IR,相较于二甲双弧并不能增进疗效、改善症状效果也无明显优势,但调脂效果更好、不良反应发生率低。
Objective: To evaluate the efficacy and safety of berberine in the treatment of polycystic ovary syndrome (PCOS) with insulin resistance (IR). Methods: From January 2014 to December 2014, 74 patients with PCOS-IR admitted to the hospital were randomly divided into control group and 37 patients in observation group according to admission sequence. After given basic ethinyl estradiol cyclophosphamide Ketone after conditioning treatment, were given dimers, berberine treatment, 3 months after the comparison of efficacy and related indicators. Results: The clinical curative effect, weight loss and total biphasic cycle of BBT in the observation group and the control group were not statistically significant (P> 0.05). The rate of dyslipidemia and adverse reactions in the observation group were lower than those in the control group. After treatment, The score was lower than before treatment, the difference was statistically significant (P <0.05). Conclusion: Berberine treatment of PCOS-IR, compared with the double-arm arc does not improve the efficacy and improve the symptoms of no obvious advantage, but the lipid-lowering effect is better, the incidence of adverse reactions is low.