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应用非同位素细胞毒试验方法，观察了肿瘤坏死因子α（ＴＮＦα）对淋巴因子激活的杀伤细胞（ＬＡＫ）介导的子宫颈癌上皮ＳｉＨａ细胞毒作用的影响。结果表明，ＴＮＦα可增强ＬＡＫ细胞对ＳｉＨａ的杀伤作用，其作用强度与ＴＮＦα的浓度有关；ＴＮＦα预处理靶细胞使ＳｉＨａ对ＬＡＫ的敏感性无明显增强（Ｐ＞０．０５）；当ＴＮＦα对ＬＡＫ及靶细胞二者都进行预处理时的细胞毒作用显著升高（Ｐ＜０．０１）。
The effect of tumor necrosis factor α (TNFα) on cytotoxicity of cervical cancer cell line SiHa mediated by lymphokine-activated killer (LAK) cells was observed by using non-isotopic cytotoxicity assay. The results showed that TNFα could enhance the cytotoxicity of SiHa on LAK cells, and its effect intensity was related to the concentration of TNFα. Pretreatment with TNFα did not significantly increase the sensitivity of SiHa to LAK (P> 0.05) And target cells both pretreatment cytotoxicity was significantly increased (P <0.01).