论文部分内容阅读
加兰他敏(Galanthamine,)是一个新的生物碱,于1952年首先从石蒜科Galanthus woronowii植物中分离得到。后来,从Lycoris radiata和Galanthus nivalis植物中也找到此生物碱。加兰他敏是一种胆碱酯酶抑制剂,它的药理作用类似毒扁豆碱。临床应用证明,加兰他敏比新斯的明(neostigmine)更易为病人耐受,对脊髓灰质炎后遗症等多种神经系统疾患造成的肢体瘫瘓,以及肌病等疾病都有较好的治疗效果。因此,引起各国医药界的重视。Baron等虽于1960年进行了它的化学合成,但因得量低而无生产意义。许多学者很重视加兰他敏植物资源的研究,迄今已发现在多种石蒜科植物中都含
Galanthamine, a new alkaloid, was first isolated in 1952 from the genus Galanthus woronowii. Later, this alkaloid was also found in Lycoris radiata and Galanthus nivalis plants. Galantamine is a cholinesterase inhibitor whose pharmacological action resembles physostigmine. Clinical application shows that galantamine is more tolerable to patients than neostigmine and has better therapeutic effects on paralyzed limbs caused by various neurological disorders such as poliomyelitis sequelae and myopathy. . Therefore, it has drawn the attention of the medical circles in various countries. Although Baron et al. Conducted its chemical synthesis in 1960, it was not productive because of low yield. Many scholars attach great importance to the research of galantamine plant resources, so far found in a variety of Amaryllidaceae plants contain