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自第一个应用于临床的有效抗病毒药物5-碘-2’-脱氧尿嘧啶核苷(IDUR)创制以来,即引起人们对核苷类化合物抗病毒作用研究的兴趣。IDUR有一定的毒性,从其类似物和衍生物的研究中寻找选择性好的抗病毒药物已获得颇有成效的进展。二十年来不断找到活性好,毒性小的治疗疱疹病毒角膜炎、脑炎、生殖器疱疹、带状疱疹、巨细胞病毒病的药物,有些并有广谱抗病毒作用,对流感或肝炎治疗也带来了希望,虽然尚未能象抗菌药物那样控制感染,改变
Since the first clinical active antiviral drug 5-iodo-2’-deoxyuridine (IDUR) was created, it has aroused people’s interest in studying the antiviral effects of nucleosides. IDUR has some toxicity, and the search for good antiviral drugs with good selectivity from the research of its analogues and derivatives has made a very good progress. Over the past two decades, we have been continuously searching for active and less toxic drugs for the treatment of herpesvirus keratitis, encephalitis, genital herpes, shingles and cytomegalovirus. Some also have a broad-spectrum antiviral effect and also treat influenza or hepatitis There is hope, though not yet able to control the infection and change like antibacterials