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何杰金病在形态学上可能难以与一些具有多形性类似Reed-Sternberg细胞的非何杰金淋巴瘤区别。近来,Dorfman等观察到由单克隆抗体PD7/26所特定的一种白细胞共同抗原(LCA)在非何杰金淋巴瘤细胞呈强阳性,而在何杰金病肿瘤细胞呈弱阳性或阴性,故对两者可能具有诊断价值。为了评价LCA对何杰金病的鉴别诊断,作者使用抗-LCA抗体(一种单克隆抗体PD7/26和2B11的混合剂,Dako,Santa Barbara,CA生产)观察了42例何杰金病和非何杰金淋巴瘤肿瘤细胞的免疫组织化学染色,并与Leu M-1相比较。结果,在24例何杰金病中,23例不存在LCA,但在18例非何杰金淋巴瘤中,16例存在LCA(包括10例具有多形性类似Reed-Sternberg细
Hodgkin’s disease may be morphologically difficult to distinguish from some non-Hodgkin’s lymphoma with pleomorphic Reed-Sternberg cells. Recently, Dorfman et al. Observed that a leukocyte common antigen (LCA) specific to the monoclonal antibody PD7 / 26 was strongly positive in non-Hodgkin’s lymphoma cells and weakly positive or negative in Hodgkin’s tumor cells, Therefore, the two may have diagnostic value. In order to evaluate the differential diagnosis of Hodgkin’s disease by LCA, the authors used 42 anti-HLC and anti-LCA antibodies (a mixture of monoclonal antibodies PD7 / 26 and 2B11, manufactured by Dako, Santa Barbara, CA) Immunohistochemical staining of non-Hodgkin lymphoma tumor cells and comparison with Leu M-1. As a result, LCA was absent in 23 of the 24 Hodgkin’s disease cases, but in 18 non-Hodgkin’s lymphoma cases, LCA was found in 16 cases (including 10 cases with polymorphic Reed-Sternberg fine