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目的研究真核细胞起始因子4E(eIF4E)在大肠良恶性肿瘤中的表达,探讨其在大肠癌发病过程中的作用及其与大肠癌生物学特性的关系。方法采用免疫组化S-P法对62例大肠癌、43例大肠腺瘤及30例正常大肠组织中的eIF4E进行检测。结果eIF4E在大肠癌中的阳性表达率显著高于大肠腺瘤,而正常大肠黏膜中未见eIF4E阳性表达。eIF4E阳性表达与肿瘤的部位、组织分化程度均无相关性,而与肿瘤浸润深度、淋巴结转移呈显著正相关。结论eIF4E过度表达在大肠癌形成过程中起重要作用,且eIF4E过度表达可作为提示大肠癌预后不良的指标之一。
Objective To investigate the expression of eIF4E in benign and malignant tumors of large intestine and its role in the pathogenesis of colorectal cancer and its relationship with the biological characteristics of colorectal cancer. Methods The immunohistochemical S-P method was used to detect eIF4E in 62 cases of colorectal cancer, 43 cases of colorectal adenoma and 30 cases of normal colorectal tissue. Results The positive expression rate of eIF4E in colorectal cancer was significantly higher than that in colorectal adenoma, while eIF4E was not found in normal colorectal mucosa. No correlation was found between the positive expression of eIF4E and the location of tumor and the degree of tissue differentiation, but positively correlated with the depth of tumor invasion and lymph node metastasis. Conclusion The overexpression of eIF4E plays an important role in the formation of colorectal cancer. Over-expression of eIF4E may be one of the indicators of poor prognosis of colorectal cancer.