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大多数高血压是由于动脉血管平滑肌张力增加,致外周血管阻力增加所引起的。多数人认为血管平滑肌张力是由细胞内钙离子浓度决定的。钙拮抗剂是一类选择性的阻滞各种易激动细胞原浆膜上钙通道的化合物,其对心血管系统的作用主要是抑制心脏和血管平滑肌的收缩功能,减慢心率和延长房室传导。其对心脏的负性心力作用和扩血管作用即是用于治疗高血压的理论基础。钙拮抗剂作为降压剂始于70年代,目前常用的有三种,即硫氮(?)酮(diltiazem)、异搏停(Verapamil)和心痛定,前二者对心脏和血管钙通道的抑制差不多相等,而心痛定对血管平滑肌的作用更强,这种特异性决定了心痛定更适用于降压治疗。本文就心
Most high blood pressure is due to increased arterial vascular smooth muscle tension, resulting in increased peripheral vascular resistance caused. Most people think that vascular smooth muscle tension is determined by intracellular calcium concentration. Calcium antagonists are a selective class of compounds that block calcium channels in the plasma membrane of easily stimulated cells. Their effects on the cardiovascular system are mainly to inhibit the contractile function of heart and vascular smooth muscle, slow down heart rate and prolong atrioventricular Conduction. Its negative cardiac effect on the heart and the role of vasodilators is the theoretical basis for the treatment of hypertension. Calcium antagonists started as antihypertensive agents in the 1970s. There are currently three commonly used drugs, diltiazem, verapamil and nifedipine, which inhibit the heart and vascular calcium channels Almost equal, and painkillers set a stronger role for vascular smooth muscle, this specificity determines the heartache is more suitable for antihypertensive treatment. This article on the heart