论文部分内容阅读
目的：探讨Ｐ选择素在急性脑梗死中的变化。方法：采用流式细胞术对４３例脑梗死患者发病１～３天及发病后１０～１４天进行Ｐ选择素的研究。结果：（１）急性脑梗死患者发病后１～３天内其血小板表面Ｐ选择素表达量较对照组显著增高（Ｐ＜０．０１）。（２）发病后１０～１４天内的血小板表面Ｐ选择素表达量较对照组增高（Ｐ＜０．０１）。（３）发病后１０～１４天的Ｐ选择素表达量较发病后１～３天显著下降（Ｐ＜０．０１）。结论：Ｐ选择素在急性脑梗死的发病过程中具有重要作用。
Objective: To investigate the changes of P-selectin in acute cerebral infarction. Methods: Flow cytometry was used to study P-selectin in 43 patients with cerebral infarction for 1-3 days after onset and 10-14 days after onset. Results: (1) The expression of P-selectin on platelet surface in patients with acute cerebral infarction was significantly higher than that in the control group (P <0.01) within 1 to 3 days after onset. (2) The expression of P-selectin on platelet surface increased from 10 to 14 days after onset (P <0.01). (3) The expression of P-selectin in 10 to 14 days after onset was significantly lower than that in 1 to 3 days after onset (P <0.01). Conclusion: P-selectin plays an important role in the pathogenesis of acute cerebral infarction.