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采用增殖细胞核抗原（ＰＣＮＡ）的免疫组化染色，研究了６例造釉细胞纤维瘤（ＡＦ）和３例造釉细胞纤维肉瘤（ＡＦＳ）的上皮成分和间叶成分的增生活性。结果显示：ＡＦＳ肿瘤性间叶成分的ＰＣ－ＮＡ标记指数（４０．８％）显著高于ＡＦ（３．２％）（Ｐ＜０．０１）；在ＡＦＳ中，上皮成分的ＰＣＮＡ标记指数明显低于间叶成分（Ｐ＜０．０１）。由此提示，ＰＣＮＡ标记可作为鉴别ＡＦ与ＡＦＳ的一个有价值的指标。
Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) was used to investigate the proliferative activity of epithelial and mesenchyme components in 6 cases of ameloblastic fibromatosis (AF) and 3 cases of ameloblastic fibrosarcoma (AFS). The results showed that the PCNA labeling index (40.8%) of tumor-associated mesenchyme in AFS was significantly higher than that in AF (3.2%) (P <0.01). In AFS, the PCNA labeling index of epithelial components was significantly Lower than the mesenchyme component (P <0.01). This suggests that PCNA markers can be used as a valuable indicator of AF and AFS.