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目的:探讨表皮生长因子受体在口腔鳞状细胞癌中的表达及其与临床的关系。材料和方法:手术切除40例口腔鳞状细胞癌组织标本,经用表皮生长因子受体单克隆抗体和免疫组织化学方法进行观察,分析其表达特点及临床表现。结果:表皮生长因子受体表达与患者的性别、年龄、发病部位、TNM分期和淋巴结转移无关(P>0.05)。高分化鳞状细胞癌的表达低于低分化(P<0.01)。结论:表皮生长因子受体表达状况与口腔鳞状细胞癌的生长有关。认为测定其表达有助于判断癌进展变化。
Objective: To investigate the expression of epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma and its clinical significance. MATERIAL AND METHODS: Forty cases of oral squamous cell carcinoma were excised surgically. The expression of EGFR and immunohistochemistry were observed by immunohistochemistry. Results: The expression of epidermal growth factor receptor was not related to the gender, age, onset site, TNM stage and lymph node metastasis (P> 0.05). The expression of well differentiated squamous cell carcinoma was lower than that of poorly differentiated squamous cell carcinoma (P <0.01). Conclusion: The expression of epidermal growth factor receptor is related to the growth of oral squamous cell carcinoma. It is believed that the determination of its expression helps to judge the progression of cancer.