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目的探讨主动免疫治疗对不明原因复发性流产患者外周血封闭抗体的影响及其在再次妊娠中的价值。方法分析390例封闭抗体阴性不明原因复发性流产患者的临床资料,并排除其他流产因素,其中340例同意主动免疫治疗为免疫治疗组,50例未同意主动免疫治疗为对照组。结果随访期间总妊娠率为93.1%(363/390)。主动免疫治疗一疗程后封闭抗体转阳性85.3%,与对照组相比,差异有统计学意义(P<0.05)。主动免疫治疗后封闭抗体阳性组妊娠成功率明显高于封闭抗体阴性组及对照组(P<0.05)。封闭抗体阳性组流产率明显低于BA阴性组及对照组(P<0.05)。封闭抗体阴性组与对照组妊娠成功率及流产率比较,差异无统计学意义(P>0.05)。结论主动免疫治疗能提高URSA患者封闭抗体阳性率及再次妊娠成功率,对URSA患者在临床上有一定的应用价值。
Objective To investigate the effect of active immunotherapy on the serum blocking antibody in patients with unexplained recurrent spontaneous abortion and its value in re-pregnancy. Methods The clinical data of 390 patients with recurrent spontaneous abortion with negative antibody were analyzed and other abortion factors were excluded. Among them, 340 patients agreed to active immunotherapy as immunotherapy group and 50 patients who did not agree to active immunotherapy as control group. Results The total pregnancy rate during follow-up was 93.1% (363/390). After a course of active immunotherapy, the positive rate of blocking antibody was 85.3%. Compared with the control group, the difference was statistically significant (P <0.05). The positive rate of pregnancy in the positive group after active immunization was significantly higher than that in the negative group and the control group (P <0.05). The abortion rate of blocking antibody positive group was significantly lower than that of BA negative group and control group (P <0.05). There was no significant difference in pregnancy success rate and abortion rate between the blocking antibody negative group and the control group (P> 0.05). Conclusion Active immunotherapy can improve the positive rate of blocking antibody in URSA patients and the success rate of pregnancy again, which has a certain clinical value in URSA patients.