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目的探讨TMSG1在胃癌中的表达与临床病理因素及预后的关系。方法采用免疫组化SP法检测胃癌及胃良性疾病的TMSG1的蛋白表达,分析与临床病理因素的关系,并完成术后的长期随访。结果 TMSG1的蛋白表达与患者的淋巴结转移,肿瘤分期密切相关(P<0.05),而与患者的年龄、肿瘤的大小、肿瘤的分级及肿瘤的类型无关(P>0.05),且TMSG1表达阳性患者的总生存期及无病生成期都明显高于阴性患者(P<0.05),多因素COX分析提示TMSG1是患者的一个独立的预后因素。结论 TMSG1在胃癌的疾病进展中起到非常重要的作用,是分析胃癌患者的一个预后指标。
Objective To investigate the relationship between the expression of TMSG1 and clinicopathological factors and prognosis in gastric cancer. Methods Immunohistochemical SP method was used to detect the protein expression of TMSG1 in gastric cancer and benign gastric diseases. The relationship between the expression of TMSG1 and clinicopathological factors was analyzed and the long-term follow-up was completed. Results The protein expression of TMSG1 was closely related to lymph node metastasis and tumor stage (P <0.05), but not to age, tumor size, tumor grade and tumor type (P> 0.05), and TMSG1 positive patients (P <0.05). The multifactorial COX analysis indicated that TMSG1 was an independent prognostic factor in patients. Conclusion TMSG1 plays a very important role in the progression of gastric cancer and is a prognostic indicator of gastric cancer.