论文部分内容阅读
目的:探讨ERα甲基化与基底细胞型乳腺癌发生发展的相关性。方法:用甲基化PCR研究60例散发性基底型乳腺癌ERα启动子甲基化情况,并研究其与临床病因素之间的关系。结果:女性散发性基底细胞型乳腺癌组织中ERα基因启动子甲基化发生率为80.0%(48/60)。ERα基因启动子甲基化与淋巴结转移情况、肿瘤分期、p53蛋白、BRCA-1蛋白和BRCA-2蛋白表达情况有相关性,与患者年龄及绝经状态无关。结论:ERα基因启动子甲基化在基底细胞型乳腺癌发生发展中可能起重要作用。
Objective: To investigate the relationship between ERα methylation and the occurrence and development of basal cell carcinoma. Methods: The methylation status of ERα promoter in 60 cases of sporadic basal type breast cancer was studied by methylation PCR, and its relationship with clinicopathological factors was studied. Results: The incidence of methylation of ERα gene was 80.0% (48/60) in female sporadic basal cell carcinoma. Methylation of ERα gene was associated with lymph node metastasis, tumor stage, p53 protein, BRCA-1 protein and BRCA-2 protein expression, but not with patient age and menopausal status. Conclusion: The promoter methylation of ERα gene may play an important role in the development of basal cell carcinoma.