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本文报告了林丹对妊娠兔和大鼠的子代致畸作用。实验兔为新西兰成熟白兔,以一对一进行交配后,每只雌兔静脉注射黄体激素10单位,以保证排卵。每组13只,共4组,实验组剂量分别为5、10和20mg/kg,以交配日为零日,自第6～18日每日经胃给药,林丹以0.5%水溶性羧甲基纤维素胶粘质配成悬液,每日新鲜配制,各组均给悬液1ml/kg,对照组仅给溶剂。自由进食和饮水。每日作一般检查,在第1、6、10、14、21和29日称重,在第29日,以苯巴比妥钠麻醉处死,取出胎仔后,作尸检,称重脑、垂体、心、肺、肝、牌、胸腺、肾、甲状腺、肾上腺、胰、膀胱、
This article reports on the teratogenic effects of lindane on the offspring of pregnant rabbits and rats. Experimental rabbits were mature New Zealand white rabbits, mating one by one, each female rabbit intravenous injection of luteinizing hormone 10 units to ensure ovulation. Each group of 13, a total of 4 groups, the experimental group doses were 5,10 and 20mg / kg, to the mating day for zero-day, from day 6 to 18 daily gastric administration, lindane with 0.5% water-soluble carboxymethyl Cellulose adhesive dubbed the suspension, freshly prepared daily, each group were given suspension 1ml / kg, the control group only to the solvent. Eat and drink freely. Daily for general examination, weighed on the 1st, 6th, 10th, 14th, 21st and 29th day. On the 29th day, the mice were anesthetized with phenobarbital and sacrificed. After removal of the fetuses, an autopsy was performed to weigh the brain, pituitary, Heart, lung, liver, brand, thymus, kidney, thyroid, adrenal, pancreas, bladder,