论文部分内容阅读
目的探讨慢性乙型肝炎患者血清甲胎蛋白(AFP)的表达水平与血清生化指标的关系。方法对120例慢性乙型肝炎患者进行包括AFP、谷丙转氨酶(ALT)、谷氨酞转肤酶(GGT)等的水平检测;比较AFP阳性患者(>20ng/ml为阳性)与AFP阴性患者的肝功能损害程度,并追踪观察AFP阳性者的AFP变化与肝功能生化指标之间的关系。对120例慢性乙型肝炎患者进行甲胎蛋白(AFP)和肝功能检测,并进行肝组织炎症分级(G)及纤维化分期(S)。结果伴随肝脏炎症及纤维化程度的增加,AFP阳性例数和数值也在增加,AFP阳性者的ALT、GGT较AFP阴性者高(P<0.01或<0.05)。随着肝功能的恢复,AFP逐渐恢复正常。结论 AFP与血清生化指标可以反映慢性乙型肝炎患者肝纤维化及炎症的程度。
Objective To investigate the relationship between serum alpha-fetoprotein (AFP) expression and serum biochemical parameters in patients with chronic hepatitis B Methods A total of 120 patients with chronic hepatitis B (AFP), alanine aminotransferase (ALT) and glutamate phthalazinase (GGT) were assayed. AFP negative patients (> 20ng / ml positive) The degree of liver damage, and follow-up observation of AFP-positive AFP changes and liver biochemical indicators of the relationship. AFP and liver function tests were performed in 120 patients with chronic hepatitis B. The grading of liver inflammation (G) and fibrosis stage (S) were performed. Results With the increase of hepatic inflammation and fibrosis, the number and the number of AFP positive cases were also increased. The ALT and GGT of AFP positive patients were higher than those of AFP negative patients (P <0.01 or <0.05). With the recovery of liver function, AFP gradually returned to normal. Conclusion AFP and serum biochemical indicators can reflect the degree of liver fibrosis and inflammation in patients with chronic hepatitis B.