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目的:探析二甲双胍联合吡格列酮治疗2型糖尿病的疗效及不良反应发生情况。方法:将2015年8月-2016年8月期间在本院接受治疗的66例2型糖尿病患者作为研究对象,以随机为原则,将其分成对照组和观察组各33例。其中对照组单用二甲双胍治疗,而观察组采取二甲双胍联合吡格列酮的治疗方案。对比2组治疗后的糖化血红蛋白水平、空腹血糖浓度、餐后2h血糖浓度及用药期间的不良反应发生情况。结果:与对照组进行比较,观察组治疗后的糖化血红蛋白、空腹血糖及餐后2h血糖均更低(p<0.05),两组的不良反应发生率对比无统计学意义。结论:二甲双胍联合吡格列酮治疗2型糖尿病安全有效。
Objective: To investigate the efficacy and side effects of metformin combined with pioglitazone in the treatment of type 2 diabetes mellitus. Methods: Sixty-six patients with type 2 diabetes treated in our hospital from August 2015 to August 2016 were randomly divided into control group and observation group with 33 cases in each group. The control group was treated with metformin only, and the observation group was treated with metformin combined with pioglitazone. The levels of HbA1c, fasting blood glucose, postprandial 2h blood glucose and adverse reactions during the treatment were compared between the two groups. Results: Compared with the control group, the HbA1c, fasting plasma glucose and postprandial 2h blood glucose in the observation group were lower (p <0.05), and the incidence of adverse reactions in the two groups was not statistically significant. Conclusions: Metformin combined with pioglitazone is safe and effective in the treatment of type 2 diabetes mellitus.