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支气管哮喘是一种以嗜酸细胞(Eos)、肥大细胞反应为主的气道慢性炎症,激活的嗜酸细胞、肥大细胞在哮喘的发病中发挥重要作用。而Eos从循环血液聚集到支气管粘膜的机理尚不完全清楚。随着细胞粘附分子的发现,人们对炎细胞浸润的机制有了更进一步的了解,现已表明,白细胞的滚动、粘附、渗出等过程均与白细胞以及血管内皮细胞表面的细胞粘附分子(CAMs)有关。CAMs是存在于细胞表面的糖蛋白,主要功能是促进细胞与细胞及细胞与组织基质的粘附。
Bronchial asthma is a chronic inflammation of the airways that is predominant with eosinophils (Eos) and mast cells. Activated eosinophils, mast cells, play an important role in the pathogenesis of asthma. The mechanism by which Eos accumulates from circulating blood to the bronchial mucosa is not fully understood. With the discovery of cell adhesion molecules, people have a better understanding of the mechanism of inflammatory cell infiltration. It has been shown that the process of leukocyte rolling, adhesion and exudation are all associated with the cell adhesion of leukocytes and the surface of vascular endothelial cells Molecular (CAMs) related. CAMs are glycoproteins that are present on the surface of cells and their primary function is to promote the adhesion of cells to cells and to the matrix of cells.