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目的研究儿童幽门螺杆菌(HP)感染后消化系统症状发生的相关性。方法对上海市某区430名4～16岁儿童进行了一次整群抽样调查,内容包括血清HP抗体检测及详细记录儿童消化系统症状,血清HP抗体阳性儿童同时进行粪HP抗原测定,有消化系统症状患儿尽可能作胃镜检查。结果430名中HP感染阳性儿童121例,感染率为28.1%,学龄前(4～6岁)、学龄期(7～12岁)、青春期(13～16岁)三个年龄阶段HP感染率分别为19%、30%、47%,HP感染阳性有消化道症状儿童90例,占HP感染阳性儿童(62名)74%,HP感染阴性有消化道症状儿童77名,占HP感染阴性儿童(258名)30%,二者在统计学上有显著差异。且以腹痛、厌食最为常见。行胃镜检查的患儿共33人,HP感染阳性27人,HP感染阴性6人,患慢性胃炎、十二指肠炎、胃溃疡、十二指肠溃疡的儿童30人,疾病检出率为90%。结论(1)HP感染在儿童中有很高的感染率,随着年龄的增长,感染率增加。(2)HP感染可以引起儿童一系列消化道症状,年龄小,症状不典型,随着年龄增长,消化道症状发病率增高,胃镜检查有较高的疾病检出率。
Objective To study the correlation of digestive system symptoms in children with Helicobacter pylori (HP) infection. Methods A total of 430 children from 4 to 16 years old in a certain district of Shanghai were enrolled in a cluster sampling survey, which included the detection of serum HP antibody and detailed records of children’s digestive system symptoms. Serum HP antibody-positive children also performed simultaneous determination of fecal HP antigen and digestive system Symptoms of children as possible gastroscopy. Results Among the 430 children with HP-positive infection, 121 cases were infected with the infection rate of 28.1%. The prevalence of HP infection among the three age groups (4 to 6 years old, school age (7 to 12 years), adolescence (13 to 16 years old) (19%, 30%, 47%). HP infection was positive in 90 children with gastrointestinal symptoms, accounting for 74% of HP infection-positive children (62 children), HP infection-negative children with gastrointestinal symptoms 77, accounting for HP infection-negative children 258) 30%, the two statistically significant differences. And to abdominal pain, anorexia is the most common. There were 33 children with gastroscopy, 27 HP positive, 6 HP negative, and 30 children with chronic gastritis, duodenitis, gastric ulcer and duodenal ulcer. The detection rate was 90 %. Conclusion (1) HP infection has a high infection rate in children, with the increase of age, the infection rate increases. (2) HP infection can cause children a series of gastrointestinal symptoms, young age, atypical symptoms, with age, the incidence of gastrointestinal symptoms increased, gastroscopy have a higher detection rate of the disease.