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正常人的淋巴细胞借助于自然杀伤(NK)细胞对于肿瘤细胞有一定的胞毒活性。在对抗肿瘤靶细胞上,NK 细胞及介导抗体依赖性细胞介导的胞毒作用(ADCC)的效应细胞(K 细胞)二者间有不少相似之处,事实上这两种细胞可能相同。向啮齿动物体内接种病毒、免疫刺激剂、肿瘤细胞及其它 IF 诱生剂可导致 NK 细胞活力的增强。体内及体外实验均已证实。IF 在迅速增强小鼠 NK 活性上具有主要作用。IF 增强人的 NK 活性也有报告。本
Normal human lymphocytes have certain cytotoxic activity on tumor cells by means of natural killer (NK) cells. There are many similarities between NK cells and effector cells (K cells) that mediate antibody-dependent cell-mediated cytotoxicity (ADCC) on tumor target cells, in fact the two cells may be the same . Inoculation of viruses, immunostimulants, tumor cells and other IF-inducing agents into rodents results in enhanced NK cell viability. In vivo and in vitro experiments have been confirmed. IF has a major role in rapidly increasing mouse NK activity. IF enhances human NK activity has also been reported. this