论文部分内容阅读
目的:分析研究胃肠道间质瘤(GIST)的临床病理及免疫组织化学特征。方法:选取2012年7月-2014年11月东莞市第三人民医院收治的患有胃肠道间质瘤的患者80例,对其临床病理以及免疫组织化学特点进行分析研究。结果:发病部位包括胃部、小肠、结肠、肠系膜、腹膜后;在显微镜下胃肠道间质瘤大部分呈现为梭形细胞、上皮样细胞以及混合型细胞;CD117、CD34以及DOG-1大部分为弥漫强阳性,平滑肌肌动蛋白(а-SMA)为局灶阳性或者部分阳性,S-100蛋白阳性表达均为局灶性。结论:胃肠道间质瘤在临床当中较为少见,以中年和老年人群居多,其病理组织排列结构呈现多样性,细胞形态多样化。然而CD117对胃肠道间质瘤细胞的广泛表达能够作为胃肠道间质瘤的临床诊断指标。
Objective: To analyze the clinicopathological and immunohistochemical features of gastrointestinal stromal tumors (GIST). Methods: From July 2012 to November 2014, 80 patients with gastrointestinal stromal tumors admitted to the Third People’s Hospital of Dongguan City were enrolled in this study. Their clinicopathological and immunohistochemical features were analyzed. Results: The sites of pathogenesis included stomach, small intestine, colon, mesentery and retroperitoneal. Most of gastrointestinal stromal tumors presented spindle cells, epithelioid cells and mixed cells under microscope; CD117, CD34 and DOG-1 Some were diffusely positive and smooth muscle actin (Î ±-SMA) was focal or partial positive, S-100 protein expression was focal. Conclusion: Gastrointestinal stromal tumors (GISTs) are relatively rare in clinical practice. They are mostly middle-aged and elderly people. The pathological organization of GISTs is diverse and its cell morphology is diverse. However, the extensive expression of CD117 on gastrointestinal stromal cells can be used as a clinical diagnostic indicator of gastrointestinal stromal tumors.