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采用静电纺丝技术成功制备出温敏性PNIPAAm/EC复合纳米纤维并使用扫描电子显微镜(SEM)、傅里叶变换红外光谱(FT-IR)、凝胶渗透色谱(GPC)及接触角(CA)对复合纤维进行表征。结果表明:制备的复合纳米纤维直径为360~400nm,当纺丝液中聚N-异丙基丙烯酰胺(PNIPAAm)与乙基纤维素(EC)的质量比为1∶2时,纤维形貌最佳,且随着EC含量增加,纤维直径减少;当温度为25℃时,材料表现为较强的亲水性,当温度为40℃时,材料疏水性明显增强。实验结果可以证明PNIPAAm/EC复合纳米纤维具有良好的温敏性能,可应用为温敏性智能型载药材料。
The thermosensitive PNIPAAm / EC composite nanofibers were successfully prepared by electrospinning technique and characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), gel permeation chromatography (GPC) and contact angle The composite fibers were characterized. The results showed that the diameter of the prepared composite nanofibers was 360-400 nm. When the mass ratio of PNIPAAm to ethyl cellulose (EC) in the spinning solution was 1: 2, the fiber morphology And the fiber diameter decreased with the increase of EC content. When the temperature was 25 ℃, the material showed strong hydrophilicity, and the hydrophobicity of the material was obviously enhanced when the temperature was 40 ℃. The experimental results can be proved PNIPAAm / EC composite nanofibers with good temperature-sensitive properties, can be applied as a smart temperature-sensitive drug-loaded materials.