论文部分内容阅读
目的探讨应用定量组织速度成像(quantitative tissue velocity imaging,QTVI)技术评价系统性红斑狼疮(systemic lupus erythematosus,SLE)患者左心室收缩与舒张功能损害的价值。方法 40例绝经期前女性SLE患者,其中SLE病程<5a者18例为SLEⅠ组,病程≥5a者22例为SLEⅡ组,同期体检健康者20例为对照组,3组行常规超声心动图检查后,应用QTVI技术检测二尖瓣环水平前壁、下壁、后间隔、侧壁、前间隔、后壁的收缩期峰值运动速度(systolic peak velocity,Vs)、舒张早期峰值运动速度(early diastolic peak velocity,Ve)、舒张晚期峰值运动速度(late diastolic peak velocity,Va),并计算Ve/Va比值,以6个位点均值代表二尖瓣环的整体运动,并进行比较。结果 SLEⅠ组左心室二尖瓣环水平各壁Vs、Va及其均值与对照组比较差异均无统计学意义(P>0.05),各壁Ve、Ve/Va及其均值均较对照组降低(P<0.05或<0.01);SLEⅡ组左心室二尖瓣环水平各壁Vs、Ve、Ve/Va及其均值均较对照组降低(P<0.05或<0.01),除侧壁外,余各壁Va均较对照组降低(P<0.05或<0.01);与SLEⅠ组比较,SLEⅡ组左心室二尖瓣环水平侧壁Vs及各壁Vs均值均降低(P<0.05或<0.01),各壁Ve、Ve/Va及其均值均降低(P<0.05或<0.01),前间隔Va降低(P<0.05);SLE患者Vs、Ve、Va、Ve/Va均与病程呈负相关(r=-0.637,P=0.000;r=-0.700,P=0.000;r=-0.367,P=0.020;r=-0.779,P=0.000)。结论应用QTVI技术可早期、敏感检测出SLE患者左心室功能异常,对临床早期防治心脏并发症有指导意义。
Objective To evaluate the value of quantitative tissue velocity imaging (QTVI) in the evaluation of left ventricular systolic and diastolic dysfunction in patients with systemic lupus erythematosus (SLE). Methods Forty SLE patients with pre-menopausal women were enrolled in this study. Twenty-five SLE patients whose SLE duration was less than 5% of the patients were SLEⅠ, 22 patients were SLEⅡ patients whose duration of SLE was more than 5 years, and 20 healthy people were selected as control group during the same period. Conventional echocardiography QTVI was used to detect systolic peak velocity (Vs), early diastolic velocities (P <0.05) in the anterior wall, inferior wall, posterior septum, lateral wall, anterior septum and posterior wall of the mitral annulus peak velocity, Ve), late diastolic peak velocity (Va), and calculated Ve / Va ratio. The 6-point mean represents the global mitral annulus movement, and compared. Results There was no significant difference in Vs, Va and its mean value between the two groups (P> 0.05). The mean values of Ve, Ve / Va and their mean in each wall were lower than those in control group P <0.05 or <0.01). Compared with the control group, the levels of Vs, Ve, Ve / Va and the average values of mitral annulus in the SLEⅡ group were lower than those in the control group (P <0.05 or <0.01) (P <0.05 or <0.01). Compared with SLEⅠ group, the Vs and the average value of Vs of left ventricular mitral valve annulus in SLEⅡgroup decreased (P <0.05 or <0.01) The values of Ve, Ve and Va both decreased (P <0.05 or <0.01) and Va decreased (P <0.05). The Vs, Ve, Va and Ve / Va of SLE patients were negatively correlated with the course of disease -0.637, P = 0.000; r = -0.700, P = 0.000; r = -0.367, P = 0.020; r = -0.779, P = 0.000). Conclusion QTVI technique can detect left ventricular dysfunction in SLE patients early and sensitively, and it is instructive to prevent and treat cardiac complications early in clinical practice.