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目的探讨普萘洛尔联合氟桂利嗪预防性治疗偏头痛患者的临床疗效。方法选取2014年8月至2015年3月吉林省长春市九台区人民医院收治的98例偏头痛患者作为研究对象,按随机数字表法将其分为观察组(50例)和对照组(48例)。对照组患者睡前顿服盐酸氟桂利嗪胶囊,观察组患者在对照组基础上口服盐酸普萘洛尔片,比较两组患者的头痛发作频率、持续时间、疼痛程度、临床治疗效果及不良反应发生情况。结果治疗后,观察组患者的头痛发作频率、疼痛视觉模拟量表(VAS)评分均明显低于对照组,头痛持续时间明显短于对照组,差异均有统计学意义(均P<0.05);观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论普萘洛尔联合氟桂利嗪预防性治疗偏头痛患者临床疗效明显,可有效缓解患者临床症状,且安全性较高。
Objective To investigate the clinical effects of propranolol and flunarizine in the prevention and treatment of migraine. Methods A total of 98 patients with migraine who were treated in Jiutai District People’s Hospital, Changchun City, Jilin Province from August 2014 to March 2015 were selected as study subjects and divided into observation group (50 cases) and control group 48 cases). Patients in the control group were treated with Flunarizine Hydrochloride capsules before bedtime. The patients in the observation group were given propranolol hydrochloride tablets orally on the basis of the control group. The frequency, duration, degree of pain, clinical effect and adverse effects of headache in both groups were compared Reaction occurred. Results After treatment, headache frequency and pain visual analog scale (VAS) scores in the observation group were significantly lower than those in the control group. The duration of headache was significantly shorter than that in the control group (all P <0.05). The total effective rate of observation group was significantly higher than that of the control group, the difference was statistically significant (P <0.05). Conclusion propranolol and flunarizine prophylactic treatment of migraine patients with significant clinical efficacy, which can effectively alleviate the clinical symptoms of patients and high safety.