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目的了解甲型肝炎病毒减毒活疫苗（Ｈ２减毒株）（以下简称甲肝活疫苗）对乙肝病毒（ＨＢＶ）感染的影响。方法对２４例成人无症状乙肝病毒携带者，皮下注射甲肝活疫苗后，观察血清ＨＢＶ标志物（ＨＢＶＭ）影响情况。结果三个月内ＨＢｅＡｇ转阴率及ＨＢｓＡｇ滴度４倍以上下降者均为３３．３３％（８／２４）。结论揭示一种嗜肝病毒可能在细胞内直接影响另一种嗜肝病毒的感染，这种因子有可能是该病毒的某种成份。
Objective To understand the effect of live attenuated Hepatitis A virus (H2 attenuated strain) (Hepatitis A live vaccine) on Hepatitis B virus (HBV) infection. Methods 24 cases of adult asymptomatic hepatitis B virus carriers, subcutaneous injection of live hepatitis A vaccine, the impact of serum HBV markers (HBVM) were observed. Results Within three months, the HBeAg negative rate and HBsAg titer decreased more than 4 times, which were 33.33% (8/24). The conclusion revealed that a Hepatitis virus may directly affect the infection of another Hepatitis virus intracellularly, which may be a component of the virus.