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[目的]评价Artemin蛋白在乳腺癌组织中的表达及其意义。[方法]应用免疫组织化学方法检测159例乳腺癌组织Artemin表达情况,分析其与乳腺癌临床病理特征和预后间的关系。[结果]乳腺癌组织中Artemin阳性率为65.4%(104/159),高于乳腺良性病变组织中的Artemin阳性率(35.7%,5/14)(χ2=4.868,P=0.027)。Artemin表达与乳腺癌TNM分期和Her-2过表达呈正相关(P=0.032,P=0.001)。Artemin蛋白阳性患者5年生存率为47.4%,而Artemin蛋白阴性患者5年生存率为70.5%,差异有统计学意义(P=0.021)。[结论 ]乳腺癌组织中Artemin的表达状况与乳腺癌侵袭转移有密切关系。
[Objective] To evaluate the expression of Artemin protein in breast cancer and its significance. [Method] The expression of Artemin in 159 cases of breast cancer tissues was detected by immunohistochemistry. The relationship between the expression of Artemin and the clinicopathological features and prognosis of breast cancer was analyzed. [Results] The positive rate of Artemin in breast cancer tissues was 65.4% (104/159), which was higher than that of benign breast lesions (35.7%, 5/14) (χ2 = 4.868, P = 0.027). Artemin expression was positively correlated with TNM staging and Her-2 overexpression in breast cancer (P = 0.032, P = 0.001). The 5-year survival rate of Artemin-positive patients was 47.4%, while that of Artemin-negative patients was 70.5%. The difference was statistically significant (P = 0.021). [Conclusion] The expression of Artemin in breast cancer is closely related to the invasion and metastasis of breast cancer.