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本文用放射免疫测定法,检测50例类风湿性关节炎患者和15例有渗出液的骨关节病患者的血清和滑膜液中铁蛋白,结果在全部滑膜液标本中均可检出铁蛋白。滑膜液中铁蛋白浓度在骨关节病患者中与血清浓度相类似;在类风湿关节炎患者中其浓度显著增高(P<0.0001),偶而为相应血清值的20倍,两组有显著差别(P<0.0001)。类风湿性关节炎患者的血清铁蛋白和滑膜液铁蛋白浓度间存在一定伴随关系(r=0.4,P<0.01),而滑膜液铁蛋白和血红蛋白浓度之间呈负性相关(r=-0.3,P<0.05)。两组间的血清铁蛋白浓度无显著差别,血清铁蛋白和血红蛋白浓度间无一定关系。
In this paper, radioimmunoassay, 50 cases of rheumatoid arthritis patients and 15 cases of rheumatoid arthritis patients with osteoarthritis serum and synovial fluid ferritin, the results of all synovial fluid specimens were detected in iron protein. The concentration of ferritin in synovial fluid was similar to serum concentration in patients with osteoarthritis; its concentration was significantly higher in patients with rheumatoid arthritis (P <0.0001) and occasionally 20 times the corresponding serum value, with significant differences between the two groups P <0.0001). There was a certain relationship between serum ferritin and synovial fluid ferritin (r = 0.4, P <0.01) in rheumatoid arthritis patients, but negative correlation between synovial fluid ferritin and hemoglobin (r = -0.3, P <0.05). Serum ferritin concentrations did not differ significantly between the two groups, with no correlation between serum ferritin and hemoglobin concentration.