论文部分内容阅读
血清胆固醇和/或甘油三酯水平的升高常常与冠心病的发生有关,不过,脂类差异的起因,及其作为与冠心病统计学相关的基础的生理关系仍不清楚。比较那些在一次心脏病发作后幸存患者一级亲属的发病率,表明遗传在发生心脏病的倾向中有作用。在幸存者的家属中,胆固醇、甘油三酯,或二者的水平增高,可能涉及三种不同的基因。本文主要讨论血清脂蛋白浓度中有关遗传变异的证据。分析了居住在苏格兰东北部的50岁以下患过心肌梗塞的患者,他们的一、二级亲属,以及包括患者配偶及其相应亲属在内的对照组。除血清脂蛋白水平外,还收集了许多其它项目,包括年龄、体重、身长的记录,肩
Elevated serum cholesterol and / or triglyceride levels are often associated with the development of coronary heart disease, but the causes of lipid differences and their physiological relationship as a basis for statistical relevance to coronary heart disease remain unclear. Comparing the incidence of first-degree relatives of those surviving a heart attack indicates that the inheritance has a role in the propensity to develop heart disease. Among survivors’ families, elevated levels of cholesterol, triglycerides, or both may involve three different genes. This article focuses on evidence of genetic variation in serum lipoprotein concentrations. Analyzed patients under 50 years of age with myocardial infarction who lived in northeastern Scotland, their first- and second-degree relatives, and control groups, including their spouses and their relatives. In addition to serum lipoprotein levels, many other items have been collected, including age, weight, length record, shoulder