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目的探讨地衣芽孢杆菌活菌胶囊对肝炎后肝硬化患者血清内毒素、超敏C反应蛋白(hs-CRP)及前降钙素(PCT)水平的影响。方法将90例乙肝后肝硬化患者随机分为观察组和对照组。两组均予以低盐饮食、保肝利尿和营养支持等基础治疗。观察组加用地衣芽孢杆菌活菌胶囊0.5 g/次,3次/d,连用6周。观察两组治疗前后血氨、血清内毒素、hs-CRP和PCT水平变化。结果治疗6周后,两组血氨和血清内毒素水平较治疗前均明显下降(P<0.05或P<0.01),且观察组患者下降程度与对照组比较更明显(P<0.05);同时两组血清hs-CRP和PCT水平较前明显下降(P<0.05或P<0.01),且观察组患者下降程度与对照组比较更明显(P<0.05)。结论地衣芽孢杆菌活菌胶囊辅助治疗乙肝后肝硬化能明显降低患者血氨和血清内毒素水平,并能下调血清hs-CRP和PCT水平,从而有利于抑制肝内局部炎症反应及降低肠黏膜的通透性。
Objective To investigate the effect of Bacillus licheniformis on serum endotoxin, hs-CRP and procalcitonin (PCT) levels in patients with posthepatitic cirrhosis. Methods Ninety patients with posthepatitic cirrhosis were randomly divided into observation group and control group. Both groups were given low-salt diet, liver and urine and nutritional support and other basic treatment. Observation group plus Bacillus licheniformis 0.5g / times, 3 times / d, once every 6 weeks. Blood ammonia, serum endotoxin, hs-CRP and PCT levels in two groups before and after treatment were observed. Results After 6 weeks of treatment, the levels of serum ammonia and serum endotoxin in both groups were significantly lower than those before treatment (P <0.05 or P <0.01), and the degree of decline in the observation group was more obvious than that in the control group (P <0.05) The levels of serum hs-CRP and PCT decreased significantly in both groups (P <0.05 or P <0.01), and the degree of decline in the observation group was more obvious than that in the control group (P <0.05). Conclusion Bacillus licheniformis adjuvant treatment of hepatitis B cirrhosis can significantly reduce the level of serum ammonia and serum endotoxin, and can down-regulate serum hs-CRP and PCT levels, which is conducive to the suppression of intrahepatic local inflammatory response and reduce the intestinal mucosa Permeability.