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  5. Acid-activatible micelleplex delivering siRNA-PD-L1 for improved cancer immunotherapy of CDK4/6 inhi

Acid-activatible micelleplex delivering siRNA-PD-L1 for improved cancer immunotherapy of CDK4/6 inhi

来源 :中国化学快报:英文版 | 被引量 : 0次 | 上传用户：wubin811030
【摘 要】
：
Cyclin-dependent kinases 4 and 6 inhibitors(CDK4/6i)have been demonstrated to trigger antitumor immunity for tumor regression.However,the therapeutic performance of CDK4/6i-meadiated cancer immunotherapy was impaired by the immunosuppressive tumor microen
【作 者】
：
Jing Gao Hanwu Zhang Fengqi Zhou Bo Hou Meiwan Chen Zhigang Xie Haijun Yu 
【机 构】
：
StateKeyLaboratoryofDrugResearch&CenterofPharmaceutics,DepartmentofMedicalUltrasound,PekingUnive
【出 处】
：
中国化学快报:英文版
【发表日期】
：
2021年6期
【关键词】
：
Cancer immunotherapy siRNA delivery Acid-activatible micelleplex CDK4/6 inhibito 
【基金项目】
：
financially supported by the National Natural Science Foundation of China(Nos.51873228 and 31671024),Basic Research Program of Shenzhen(No.JCYJ20180227175420974),Science and Technology Development Fun
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Cyclin-dependent kinases 4 and 6 inhibitors(CDK4/6i)have been demonstrated to trigger antitumor immunity for tumor regression.However,the therapeutic performance of CDK4/6i-meadiated cancer immunotherapy was impaired by the immunosuppressive tumor microen
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