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本文采用ＫｉｒｂｙＢａｕｅｒ琼脂扩散法及最小浓度抑菌试验对临床所分离的７９株肺炎杆菌进行药物敏感性研究。通过琼脂扩散法检测的结果为除２株外所有分离菌株均对２种或２种以上抗生素耐药。其中对氨苄青霉素、羧苄青霉素、庆大霉素、丁胺卡那霉素、妥布霉素、先锋霉素Ｖ、灭滴灵等７种抗生素的耐药率分别为８８．６％，８６．１％，２０．３％，８．８％，１０．１％，２２．０％，９８．７％。该法检测后的所有多重耐药肺炎杆菌又进行了最小抑菌浓度试验，其结果为国产环丙沙星的体外抗菌活性（ＭＩＣ_（５０）＝０．１６μｇ／ｍｌ）明显高于丁胺卡那霉素（ＭＩＣ_（５０）＝９．１８μｇ／ｍｌ）以及头孢噻肟（ＭＩＣ_（５０）＝１．８μｇ／ｍｌ）。而羧苄青霉素抑菌活性最差（ＭＩＣ_（５０）＞２００μｇ／ｍｌ）。
In this paper, KirbyBauer agar diffusion method and the minimum concentration of antibacterial test of clinical isolates of 79 Klebsiella pneumoniae drug sensitivity studies. As a result of the agar diffusion assay, all the isolates except two strains were resistant to two or more antibiotics. Among them, the resistance rates to ampicillin, carbenicillin, gentamicin, amikacin, tobramycin, cephalosporin V and metronidazole were 88.6%, 86% .1%, 20.3%, 8.8%, 10.1%, 22.0%, 98.7%. The method of testing all the multi-drug resistant Klebsiella pneumoniae and the minimum inhibitory concentration of the test, the results of domestic ciprofloxacin in vitro antibacterial activity (MIC_ (50) = 0.16μg / ml) was significantly higher than amikacin (MIC_ (50) = 9.18 μg / ml) and cefotaxime (MIC_ (50) = 1.8 μg / ml). The antibacterial activity of carbenicillin was the worst (MIC 50> 200μg / ml).