论文部分内容阅读
目的检测并比较对照组和接振作业人群外周血肿瘤坏死因子-α(TNF-α)水平的差别,探讨其是否适合作为手臂振动病诊断和分级的临床实验室辅助检测指标。方法酶联免疫吸附法检测目标人群外周血TNF-α水平。结果 94.12%手臂振动病病人(病例组)TNF-α水平超过正常参考值8.1 pg/ml,手臂振动病病人(接振组)TNF-α浓度明显高于对照组(P<0.01)。但手臂振动病人中白指组与非白指组及三个不同工龄组间(5年及以下、6~10年、11年及以上)TNF-α水平比较,差异均无统计学意义。结论手臂振动病病人血中TNF-α异常增高可能与病人血管损伤所致炎症有关,但未呈现出剂量—效应关系趋势。
Objective To detect and compare the difference of tumor necrosis factor-α (TNF-α) levels in peripheral blood between control group and surge-operated group, and to explore whether it is suitable as a clinical laboratory assistant detection index for the diagnosis and grading of arm vibration disease. Methods Enzyme-linked immunosorbent assay was used to detect the level of TNF-α in the peripheral blood of the target population. Results The level of TNF-α in 94.12% of arm vibration patients (case group) exceeded the normal reference value of 8.1 pg / ml, and the level of TNF-α in arm vibration patients was significantly higher than that of control group (P <0.01). However, there was no significant difference in the levels of TNF-α between white finger group and non-white finger group and three different working age groups (5 years and under, 6 to 10 years, 11 years and above) in arm vibration patients. Conclusions The abnormal increase of TNF-α in the blood of patients with arm-shaking disease may be related to the inflammation caused by vascular injury in patients, but no dose-response relationship exists.