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本文报道用华支睾吸虫与二甲基亚硝胺诱发动物肝癌的实验结果。Ａ组每只金地鼠通过胃管人工感染华支睾吸虫囊蚴，３０ｄ后当鼠粪中查见华支睾吸由卵时开始自由饮服０．００２５％二甲基亚硝胺溶液１７周，结果１１只鼠中４只诱发肝癌，１只诱发肝胆管癌和５只肝硬变。Ｂ组每只鼠仅自由饮服０．００２５％二甲基亚硝胺溶液１７周，１５只鼠中３只诱发肝癌，５只肝硬变。Ｃ组每只鼠仅通过胃管人工感染华支睾吸虫囊蚴，不饮服二甲基亚硝胺，１２只鼠中仅６只发生肝硬变。空白对照的１５只鼠均未发现病变。结果显示金地鼠饮服二甲基亚硝胺可引起肝细胞和胆管细胞恶变，而华支睾吸虫在肝内的寄生，可促使肝癌的发生。
This article reports the experimental results of hepatocarcinogenesis induced by Clonorchis sinensis and dimethylnitrosamine in animals. In group A, each golden hamster was artificially infected with metacercaria of Clonorchis sinensis by gastric tube. After 30 days, the rats were randomly given 0.0025% dimethylnitrosamine solution for 17 weeks , 4 of 11 rats induced liver cancer, 1 induced hepatocellular carcinoma and 5 cirrhosis. In group B, only 0.0025% dimethylnitrosamine solution was given to each mouse for 17 weeks. Three of the 15 mice induced liver cancer and 5 cirrhosis. Each mouse in Group C was only artificially infected with metacercaria of Clonorchis sinensis by gastric tube, did not receive dimethylnitrosamine, and only 6 out of 12 mice developed cirrhosis. Fifteen mice in the blank control group showed no pathological changes. The results showed that gilts diet dimethylnitrosamine can cause malignant hepatocytes and bile duct cells, and Clonorchis sinensis parasitic in the liver, can promote the occurrence of liver cancer.