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1977年Rizzetto及其同道在意大利乙肝病毒携带者中发现δ型肝炎抗原(HDAg),认为是一种新的核抗原。出现这抗种HDAg的携带者重症慢活肝以及肝硬化的发生率较高,同时这种抗原也参与一定数量的暴发性肝炎的发病。黑猩猩接种试验提示这
In 1977, Rizzetto and his colleagues found the hepatitis delta virus (HDAg) in Italy among hepatitis B virus carriers and considered it a new nuclear antigen. Occurrence of this anti-species HDAg carriers of severe chronic liver and liver cirrhosis of the higher incidence, while this antigen is also involved in the incidence of a certain number of fulminant hepatitis. Chimpanzee vaccination tests suggest this